PROGRESS: Completed Project

PROJECT REF: INMT3

PROJECT TITLE: CMOS 集成電路 DNA 檢測器 CMOS IC DNA Sensor

PROJECT DESCRIPTION:
香港科技大學電機及電子工程系陳文新教授領導的研究小組近日成功研發了一種新型的集成電路DNA檢測器。該器件採用CMOS光學陣列元件﹐通過量度芯片表面的遮光率以鑒別 預先經納米金屬附着處理的DNA分子的類型。該檢測器芯片表面經納米技術處理以獲得疏水/親水相間的結構﹐可有效控制待測DNA樣品與試劑的反應位置。與傳統使用光致熒光及顯微鏡掃描技術的DNA檢測器相比, 該檢測器毋需紫外光源及顯微鏡等設備﹐體型小巧﹐使用簡便﹐成本低廉。該檢測器可廣泛應用于生物醫藥領域之DNA鑒別測試﹐如病毒檢測﹐病理分析﹐基因工程等。該技術已申請一項專利。我們竭誠歡迎各廠商垂詢合作。 Technology: A Novel DNA sensor chip based on optical detection using CMOS imaging IC. It detects the opacity under room light in determining whether there is a match between the testing DNA agent and the unknown DNA samples attached with nano metal particles. In order to confine the DNA samples on the specific areas of testing agents, nano treatment has been applied to create hydrophobic and hydrophilic patterns on the surface. Advantages: Comparing with other DNA sensors using fluorescence and microscopic detection, it is convenient (without UV or micro-scanning systems), compact, and low cost. Applications: Identify DNA fragments for bio-medical applications: virus detection, disease analysis, gene mutation.

FOCUS AREA(S): Medical Diagnostics and Devices

KEYWORDS: CMOS 集成電路, DNA 檢測器, CMOS IC DNA Sensor,

MODE OF COLLABORATION: Technology Licensing, Further R&D Collaboration

STATUS PATENT: NA

PATENT NO: NA

ORGANIZATION: Hong Kong University of Science and Technology R and D Corporation Limited

CONTACT PERSON: Shirley Woo

EMAIL: cawoosw@ust.hk

TEL: (852)-23587918

FAX: (852)-23582751

WEBSITE: http://rdc.ust.hk

DATE: 03/01/2005